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KMID : 1036920220270020113
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Annals of Pediatric Endocrinology & Metabolism
2022 Volume.27 No. 2 p.113 ~ p.120
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The association between vitamin D deficiency and metabolic syndrome in Ukrainian adolescents with overweight and obesity
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Shulhai Anna-Mariia
Pavlyshyn Halyna
Oleksandra Shulhai
Furdela Victoria
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Abstract
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Purpose: This work aims to determine the association between vitamin D deficiency and metabolic syndrome in overweight and obese adolescents from Ukraine.
Methods: Anthropometric measurements were taken and general and biochemical examinations were performed on 136 obese and overweight adolescents and 60 adolescents with normal body weight. The vitamin D status was determined using 25-hydroxyvitamin D (25(OH)D) (calcidiol) levels in blood serum. To establish the factors influencing vitamin D status, the subjects were asked to answer a questionnaire and 2007 International Diabetes Federation diagnostic criteria were used to determine the incidence of metabolic syndrome. All research results were processed statistically.
Results: A calcidiol sufficiency level was found in 3.9% of obese adolescents and 6.7% of overweight adolescents. Metabolic syndrome was found in 64.4% of obese adolescents with vitamin D deficiency, and in 26.2% of overweight adolescents. Factors associated with an increased risk of developing vitamin D deficiency in adolescents with metabolic syndrome included male sex (P=0.042), low income per family member (P=0.040), daily milk consumption of up to 1 cup per day (P=0.001), physical activity (P=0.001), duration of outdoor stays (P=0.001), and passive rest in front of a computer or television (P=0.001). Adolescents with metabolic syndrome were found predominance of body mass index (P<0.001), waist circumference (P<0.001), fasting blood glucose level (P<0.001), and decreased calcidiol level (P=0.022). Among metabolic syndrome components, vitamin D deficiency was strongly associated with waist circumference and increased fasting blood glucose (P<0.05).
Conclusions: Vitamin D deficiency is prevalent in overweight and obese adolescents from Ukraine. Vitamin D deficiency is associated with metabolic syndrome criteria in overweight and obese adolescents.
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KEYWORD
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Vitamin D, Adolescents, Overweight, Obesity, Metabolic syndrome
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